Size :100ul
Clone Number:
Aliases:Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L;
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:O14763
Immunogen:Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
Raised in:Mouse
Species Reactivity:Human,Mouse
Tested Applications:ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200
Background:Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:Affinity purified
Conjugate:Non-conjugated
Buffer:Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:TNFRSF10B
Research Areas:Cancer?Cardiovascular?Cell biology;Signal transduction