Size :50ul
Clone Number:1D12
Aliases:Dickkopf-related protein 1 (Dickkopf-1) (Dkk-1) (hDkk-1) (SK), DKK1
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O94907
Immunogen:A synthesized peptide derived from human DKK1
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000
Background:Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity).
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DKK1
Research Areas:Cardiovascular; Developmental biology; Immunology; Stem cells