SNX27 Antibody - Cat. #: CSB-PA842704LA01HU

CSB-PA842704LA01HU

Size :50ug

Clone Number:

Aliases:KIAA0488 antibody; Methamphetamine responsive transcript 1 antibody; MGC126871 antibody; MGC126873 antibody; MGC20471 antibody; MRT1 antibody; MY014 antibody; OTTHUMP00000042487 antibody; RP11-98D18.12 antibody; SNX27 antibody; SNX27_HUMAN antibody; Sorting nexin family member 27 antibody; Sorting nexin-27 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96L92

Immunogen:Recombinant Human Sorting nexin-27 protein (458-497AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200

Background:Involved in the retrograde transport from endosome to plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins. Following internalization, endocytosed transmembrane proteins are delivered to early endosomes and recycled to the plasma membrane instead of being degraded in lysosomes. SNX27 specifically binds and directs sorting of a subset of transmembrane proteins containing a PDZ-binding motif at the C-terminus: following interaction with target transmembrane proteins, associates with the retromer complex, preventing entry into the lysosomal pathway, and promotes retromer-tubule based plasma membrane recycling. SNX27 also binds with the WASH complex. Interacts with membranes containing phosphatidylinositol-3-phosphate (PtdIns(3P)). May participate in establishment of natural killer cell polarity. Recruits CYTIP to early endosomes.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:Non-conjugated

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:SNX27

Research Areas:Signal transduction