Size :50ug
Clone Number:
Aliases:dJ710H13.1 antibody; Protein sna antibody; Protein snail homolog 1 antibody; Protein snail homolog antibody; SLUGH2 antibody; SNA antibody; Sna protein antibody; SNAH antibody; SNAI antibody; snai1 antibody; SNAI1_HUMAN antibody; Snail 1 homolog antibody; Snail 1 zinc finger protein antibody; SNAIL antibody; Snail family transcriptional repressor 1 antibody; Snail homolog 1 (Drosophila) antibody; SNAIL, Drosophila, homolog of, 1 antibody; SNAIL1 antibody; Zinc finger protein SNAI1 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O95863
Immunogen:Recombinant Human Zinc finger protein SNAI1 protein (1-264AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA
Background:Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5\'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Biotin
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:SNAI1
Research Areas:Epigenetics and Nuclear Signaling; Cancer; Cardiovascular