Size :50ul
Clone Number:
Aliases:CRCS3 antibody; FLJ16482 antibody; hSMAD 7 antibody; hSMAD7 antibody; MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody; MAD antibody; Mad homolog 7 antibody; MAD homolog 8 antibody; MAD mothers against decapentaplegic homolog 7 antibody; MADH 7 antibody; MADH 8 antibody; MADH6 antibody; MADH7 antibody; MADH8 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody; Mothers against decapentaplegic homolog 7 antibody; Mothers against decapentaplegic homolog 8 antibody; Mothers against DPP homolog 7 antibody; Mothers against DPP homolog 8 antibody; SMA- AND MAD-RELATED PROTEIN 7 antibody; SMAD 7 antibody; SMAD antibody; SMAD family member 7 antibody; SMAD, mothers against DPP homolog 7 (Drosophila) antibody; SMAD, mothers against DPP homolog 7 antibody; SMAD6 antibody; Smad7 antibody; SMAD7_HUMAN antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:O15105
Immunogen:Synthetic peptide of Human SMAD7
Raised in:Rabbit
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, IHC; ELISA:1:2000-1:10000, IHC:1:50-1:200
Background:The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen affinity purification
Conjugate:Non-conjugated
Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:SMAD7
Research Areas:Epigenetics and Nuclear Signaling;Signal transduction