Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Stem Cells
Uniprot NO.:Q61488
Uniprot Entry Name:DHH_MOUSE
Gene Names:Dhh
Species:Mus musculus (Mouse)
Source:E.Coli
Expression Region:24-198aa
Sequence:IIGPGRGPVG RRRYVRKQLV PLLYKQFVPS MPERTLGASG PAEGRVTRGS ERFRDLVPNY NPDIIFKDEE NSGADRLMTE RCKERVNALA IAVMNMWPGV RLRVTEGWDE DGHHAQDSLH YEGRALDITT SDRDRNKYGL LARLAVEAGF DWVYYESRNH IHVSVKADNS LAVRAGG
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:20.0 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by its ability to induce alkaline phosphatase production by murine MC3T3E1 cells is 520 ?g/ml.
Purity:>98% as determined by SDSPAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered PBS, pH 7.4,1 mM DTT, 0.05 % Tween-80
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:DHH,
Relevance:Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
PubMed ID:7916661; 7720571
Function:Intercellular signal essential for a variety of patterning events during development. May function as a spermatocyte survival factor in the testes. Essential for testes development.
Involvement in disease:
Subcellular Location:Desert hedgehog protein N-product: Cell membrane, Lipid-anchor, Extracellular side, Note=The N-terminal peptide remains associated with the cell surface, SUBCELLULAR LOCATION: Desert hedgehog protein C-product: Secreted, extracellular space
Protein Families:Hedgehog family
Tissue Specificity:Expressed in adult testes. Not expressed in limb buds.
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=324688
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:13363
STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000023737
OMIM Database Link: