Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:Q02223
Uniprot Entry Name:TNR17_HUMAN
Gene Names:TNFRSF17,BCM,BCMA
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:5-54aa
Sequence:AGQCSQNEYF DSLLHACIPC QLRCSSNTPP LTCQRYCNAS VTNSVKGTNA
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:5.4 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by its ability to inhibit APRIL-mediated proliferation of anti-IgM stimulated murine B cells is no less than 40 ng/ml, corresponding to a specific activity of ? 2.5 × 104 IU/mg in the presence of 100 ng/ml human APRIL.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:B-cell maturation protein,
Relevance:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. {ECO:0000269|PubMed:10801128, ECO:0000269|PubMed:10903733, ECO:0000269|PubMed:10973284}.
PubMed ID:1396583; 8165126; 11528522; 17825416; 10493829; 15616553; 10903733; 10801128; 10973284; 10908663; 12721620; 15542592
Function:Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK.
Involvement in disease:A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.
Subcellular Location:Cell membrane, Single-pass type III membrane protein, Endomembrane system, Single-pass type III membrane protein
Protein Families:
Tissue Specificity:Expressed in mature B-cells, but not in T-cells or monocytes.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11913
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2556
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:608
STRING Database Link:https://string-db.org/network/9606.ENSP00000053243
OMIM Database Link:https://www.omim.org/entry/109545109545109545