Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein(TNFRSF13C) (Active)

Recombinant Human Tumor necrosis factor receptor superfamily member 13C protein(TNFRSF13C) (Active)

CSB-AP002181HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Cancer

Uniprot NO.:Q96RJ3

Uniprot Entry Name:TR13C_HUMAN

Gene Names:TNFRSF13C,BAFFR,BR3

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:1-76aa

Sequence:MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

Protein Description:Partial

Tag Info:Tag-Free

Mol. Weight:7.8 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by its ability to block BAFF induced mouse splenocyte survival is 1.0-5.0 µg/ml in the presence of 1.0 ?g/ml of rHuBAFF.

Purity:>95% as determined by SDS-PAGE.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 8.0, 500 mM NaCl

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:B-cell-activating factor receptor, BAFF-R, BLyS receptor 3, CD antigen CD268,

Relevance:B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:11591325, ECO:0000269|PubMed:12387744}.

PubMed ID:11509692; 10591208; 11591325; 12387744; 12755599; 12721620; 12715002; 16840730; 16160919; 19666484

Function:B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.

Involvement in disease:Immunodeficiency, common variable, 4 (CVID4)

Subcellular Location:Membrane, Single-pass type III membrane protein

Protein Families:

Tissue Specificity:Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.

Paythway:NF-kappaBsignalingpathway

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:17755

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=344088

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:115650

STRING Database Link:https://string-db.org/network/9606.ENSP00000291232

OMIM Database Link:https://www.omim.org/entry/606269606269606269

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