Recombinant Human Trefoil factor 2 protein(TFF2) (Active)

Recombinant Human Trefoil factor 2 protein(TFF2) (Active)

CSB-AP000351HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Cell Biology

Uniprot NO.:Q03403

Uniprot Entry Name:TFF2_HUMAN

Gene Names:TFF2,SML1

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:24-129aa

Sequence:EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKS VEDCHY

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:12.0 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human MCF-7 cells is less than 10 ng/ml, corresponding to a specific activity of ? 1.0 × 105 IU/mg.

Purity:>97% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130mM NaCl

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:Spasmolysin, SP

Relevance:Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity). {ECO:0000250}.

PubMed ID:2303034; 9070946; 10950923; 15489334

Function:Inhibits gastrointestinal motility and gastric acid secretion. Could function as a structural component of gastric mucus, possibly by stabilizing glycoproteins in the mucus gel through interactions with carbohydrate side chains (By similarity).

Involvement in disease:

Subcellular Location:Secreted

Protein Families:

Tissue Specificity:Stomach.

Paythway:

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11756

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2979

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:7032

STRING Database Link:https://string-db.org/network/9606.ENSP00000291526

OMIM Database Link:https://www.omim.org/entry/182590182590182590

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