Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Signal Transduction
Uniprot NO.:P62328
Uniprot Entry Name:TYB4_HUMAN
Gene Names:TMSB4X,TB4X,THYB4,TMSB4
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:2-44aa
Sequence:SDKPDMAEIE KFDKSKLKKT ETQEKNPLPS KETIEQEKQA GES
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:4.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by its ability to produce a protective effect against hydrogen peroxide in primary lung fibroblasts is in a concentration range of 0.5 - 10 ?g/ml.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered concentrated solution in 20 mM PB, pH 7.4.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:T beta-4,
Relevance:Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}.; Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase. {ECO:0000250}.
PubMed ID:3500230; 16010977; 1999398; 6548414; 18669648; 19608861; 20068231; 21269460; 21406692; 22223895; 10848969; 23009842
Function:Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.
Involvement in disease:
Subcellular Location:Cytoplasm, cytoskeleton
Protein Families:Thymosin beta family
Tissue Specificity:Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells.
Paythway:Regulationofactincytoskeleton
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11881
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=437277
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:7114
STRING Database Link:https://string-db.org/network/9606.ENSP00000370007
OMIM Database Link:https://www.omim.org/entry/300159300159300159