Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Signal Transduction
Uniprot NO.:P31431
Uniprot Entry Name:SDC4_HUMAN
Gene Names:SDC4
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:19-145aa
Sequence:ESIRETEVID PQDLLEGRYF SGALPDDEDV VGPGQESDDF ELSGSGDLDD LEDSMIGPEV VHPLVPLDNH IPERAGSGSQ VPTEPKKLEE NEVIPKRISP VEESEDVSNK VSMSSTVQGS NIFERTE
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:13.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The specific activity is determined by binding ability in a functional ELISA. Immobilized rHuSYND4 at 500 ng/ml (100 ?l/well) can bind rHubFGF with a linear range of 0.1-10 ng/ml.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:SYND4, Ryudocan core protein
Relevance:Cell surface proteoglycan that bears heparan sulfate.
PubMed ID:1500433; 7916598; 8797100; 14702039; 11780052; 15489334; 8889549; 9169435; 14675776; 16007225; 21269460; 24275569; 11456484; 12842047; 16533050
Function:Cell surface proteoglycan that bears heparan sulfate. Regulates exosome biogenesis in concert with SDCBP and PDCD6IP
Involvement in disease:
Subcellular Location:Isoform 1: Membrane, Single-pass type I membrane protein, Secreted
Protein Families:Syndecan proteoglycan family
Tissue Specificity:Expressed in epithelial and fibroblastic cells.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:10661
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=632267
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:6385
STRING Database Link:https://string-db.org/network/9606.ENSP00000361818
OMIM Database Link:https://www.omim.org/entry/600017600017600017