Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:O14944
Uniprot Entry Name:EREG_HUMAN
Gene Names:EREG
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:60-108aa
Sequence:VAQVSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:5.6 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 × 105 IU/mg.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:EPR,
Relevance:Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269|PubMed:9419975}.
PubMed ID:9337852; 14702039; 15489334; 9419975; 14572630; 16959974
Function:Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation
Involvement in disease:
Subcellular Location:Epiregulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Proepiregulin: Cell membrane, Single-pass type I membrane protein
Protein Families:
Tissue Specificity:In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.
Paythway:ErbBsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:3443
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=115263
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:2069
STRING Database Link:https://string-db.org/network/9606.ENSP00000244869
OMIM Database Link:https://www.omim.org/entry/602061602061602061