Recombinant Human Proepiregulin [Cleaved into: Epiregulin protein(EREG) (Active)

Recombinant Human Proepiregulin [Cleaved into: Epiregulin protein(EREG) (Active)

CSB-AP002621HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Cancer

Uniprot NO.:O14944

Uniprot Entry Name:EREG_HUMAN

Gene Names:EREG

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:60-108aa

Sequence:VAQVSITKCS SDMNGYCLHG QCIYLVDMSQ NYCRCEVGYT GVRCEHFFL

Protein Description:Partial

Tag Info:Tag-Free

Mol. Weight:5.6 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is less than 2 ng/ml, corresponding to a specific activity of ? 5.0 × 105 IU/mg.

Purity:>97% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:EPR,

Relevance:Ligand of the EGF receptor/EGFR and ERBB4. May be a mediator of localized cell proliferation. As a mitogen it may stimulate cell proliferation and/or angiogenesis. {ECO:0000269|PubMed:9419975}.

PubMed ID:9337852; 14702039; 15489334; 9419975; 14572630; 16959974

Function:Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation

Involvement in disease:

Subcellular Location:Epiregulin: Secreted, extracellular space, SUBCELLULAR LOCATION: Proepiregulin: Cell membrane, Single-pass type I membrane protein

Protein Families:

Tissue Specificity:In normal adults, expressed predominantly in the placenta and peripheral blood leukocytes. High levels were detected in carcinomas of the bladder, lung, kidney and colon.

Paythway:ErbBsignalingpathway

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:3443

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=115263

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:2069

STRING Database Link:https://string-db.org/network/9606.ENSP00000244869

OMIM Database Link:https://www.omim.org/entry/602061602061602061

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