Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P05120
Uniprot Entry Name:PAI2_HUMAN
Gene Names:SERPINB2,PAI2,PLANH2
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:1-415aa
Sequence:MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA MVYMGSRGST EDQMAKVLQF NEVGANAVTP MTPENFTSCG FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE LLESEITYDK LNKWTSKDKM AEDEVEVYIP QFKLEEHYEL RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMH KITNCILFFG RFSSP
Protein Description:Full Length
Tag Info:Tag-Free
Mol. Weight:46.6 kDa
Biological_Activity:Fully biologically active when compared to standard. The biologically active was determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37 °C. Half maximal inhibition against 1.0 ?g/ml of single chain tPA was at a concentration of 1.0 ?g/ml.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered 20 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1 mM Cysteine, with 5 % Trehalose
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:PAI-2, Placental plasminogen activator inhibitor, Serpin B2, Urokinase inhibitor,
Relevance:Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
PubMed ID:3029122; 3325828; 3496414; 3257578; 2494165; 2303256; 15489334; 1286667; 14732874; 21269460; 10368272; 10391209
Function:Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell-derived PAI-1.
Involvement in disease:
Subcellular Location:Cytoplasm, Secreted, extracellular space
Protein Families:Serpin family, Ov-serpin subfamily
Tissue Specificity:
Paythway:Complementandcoagulationcascades
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:8584
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=594481
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:5055
STRING Database Link:https://string-db.org/network/9606.ENSP00000299502
OMIM Database Link:https://www.omim.org/entry/173390173390173390