Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Stem Cells
Uniprot NO.:Q13253
Uniprot Entry Name:NOGG_HUMAN
Gene Names:NOG
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:M+28-232aa
Sequence:M+QHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGAAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:23.2 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inhibiting BMP-4- induced alkaline phosphatase production of murine ATDC5 cells is less than 3.0 ng/ml, corresponding to a specific activity of ? 3.3 × 105 IU/mg in the presence of 5 ng/ml rHuBMP-4.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered 30 % acetonitrile, 0.1 % TFA
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:
Relevance:Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 (PubMed:21976273). {ECO:0000269|PubMed:12478285, ECO:0000269|PubMed:21976273}.
PubMed ID:7666191; 15489334; 21976273; 24098149; 12478285; 10080184; 11846737; 11545688; 12089654; 11857750; 15770128; 17668388; 20503332
Function:Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Essential for cartilage morphogenesis and joint formation. Inhibits chondrocyte differentiation through its interaction with GDF5 and, probably, GDF6
Involvement in disease:Symphalangism, proximal 1A (SYM1A); Multiple synostoses syndrome 1 (SYNS1); Tarsal-carpal coalition syndrome (TCC); Stapes ankylosis with broad thumb and toes (SABTS); Brachydactyly B2 (BDB2)
Subcellular Location:Secreted
Protein Families:Noggin family
Tissue Specificity:
Paythway:TGF-betasignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:7866
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=248201
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:9241
STRING Database Link:https://string-db.org/network/9606.ENSP00000328181
OMIM Database Link:https://www.omim.org/entry/184460184460184460