Recombinant Human Neurotrophin-4 protein(NTF4) (Active)

Recombinant Human Neurotrophin-4 protein(NTF4) (Active)

CSB-AP002831HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Neuroscience

Uniprot NO.:P34130

Uniprot Entry Name:NTF4_HUMAN

Gene Names:NTF4,NTF5

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:81-210aa

Sequence:M+GVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:14.1 kDa

Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg

Purity:>97% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 5.5

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:NT-4, NT-5, Neutrophic factor 4

Relevance:Target-derived survival factor for peripheral sensory sympathetic neurons.

PubMed ID:1742028; 1313578; 15489334; 10631974; 19765683; 20215012

Function:Target-derived survival factor for peripheral sensory sympathetic neurons.

Involvement in disease:Glaucoma 1, open angle, O (GLC1O)

Subcellular Location:Secreted

Protein Families:NGF-beta family

Tissue Specificity:Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.

Paythway:MAPKsignalingpathway

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:8024

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=266902

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:4909

STRING Database Link:https://string-db.org/network/9606.ENSP00000301411

OMIM Database Link:https://www.omim.org/entry/162662162662162662

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