Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Neuroscience
Uniprot NO.:P34130
Uniprot Entry Name:NTF4_HUMAN
Gene Names:NTF4,NTF5
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:81-210aa
Sequence:M+GVSETAPAS RRGELAVCDA VSGWVTDRRT AVDLRGREVE VLGEVPAAGG SPLRQYFFET RCKADNAEEG GPGAGGGGCR GVDRRHWVSE CKAKQSYVRA LTADAQGRVG WRWIRIDTAC VCTLLSRTGR A
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:14.1 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by the dose-dependent induction of choline acetyl transferase activity in rat basal forebrain primary septal cell cultures is less than 50 ng/ml, corresponding to a specific activity of > 2.0 × 104 IU/mg
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 5.5
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:NT-4, NT-5, Neutrophic factor 4
Relevance:Target-derived survival factor for peripheral sensory sympathetic neurons.
PubMed ID:1742028; 1313578; 15489334; 10631974; 19765683; 20215012
Function:Target-derived survival factor for peripheral sensory sympathetic neurons.
Involvement in disease:Glaucoma 1, open angle, O (GLC1O)
Subcellular Location:Secreted
Protein Families:NGF-beta family
Tissue Specificity:Highest levels in prostate, lower levels in thymus, placenta, and skeletal muscle. Expressed in embryonic and adult tissues.
Paythway:MAPKsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:8024
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=266902
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:4909
STRING Database Link:https://string-db.org/network/9606.ENSP00000301411
OMIM Database Link:https://www.omim.org/entry/162662162662162662