Recombinant Human C-X-C motif chemokine 11 protein(CXCL11) (Active)

CSB-AP000731HU

Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Immunology

Uniprot NO.:O14625

Uniprot Entry Name:CXL11_HUMAN

Gene Names:CXCL11,ITAC,SCYB11,SCYB9B

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:22-94aa

Sequence:FPMFKRGRCL CIGPGVKAVK VADIEKASIM YPSNNCDKIE VIITLKENKG QRCLNPKSKQ ARLIIKKVER KNF

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:8.3 kDa

Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human IL-2 activated human T-lymphocytes is in a concentration range of 0.1-10 ng/ml.

Purity:>97% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:Beta-R1, Interferon gamma-inducible protein 9, IP-9, Interferon-inducible T-cell alpha chemoattractant, I-TAC

Relevance:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

PubMed ID:8798467; 9370294; 9625760; 10233762; 10386863; 10395932; 15489334; 9730616; 18645041; 15273303

Function:Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses.

Involvement in disease:

Subcellular Location:Secreted

Protein Families:Intercrine alpha (chemokine CxC) family

Tissue Specificity:High levels in peripheral blood leukocytes, pancreas and liver astrocytes. Moderate levels in thymus, spleen and lung. Low levels in placenta, prostate and small intestine. Also found in epidermal basal layer keratinocytes in skin disorders.

Paythway:Chemokinesignalingpathway

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:10638

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=632592

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:6373

STRING Database Link:https://string-db.org/network/9606.ENSP00000306884

OMIM Database Link:https://www.omim.org/entry/604852604852604852