Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:P12643
Uniprot Entry Name:BMP2_HUMAN
Gene Names:BMP2,BMP2A
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:283-396aa
Sequence:M+QAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:13 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 200 ng/ml, corresponding to a specific activity of ? 5.0 × 103 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 ?m filtered 10 mM Sodium citrate, pH3.5
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:BMP-2, BMP-2A
Relevance:Induces cartilage and bone formation.
PubMed ID:3201241; 11780052; 9265423; 15020244; 20555025; 10074410
Function:Induces cartilage and bone formation
Involvement in disease:
Subcellular Location:Secreted
Protein Families:TGF-beta family
Tissue Specificity:Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Paythway:Hipposignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:1069
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=73853
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:650
STRING Database Link:https://string-db.org/network/9606.ENSP00000368104
OMIM Database Link:https://www.omim.org/entry/112261112261112261