Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Microbiology
Uniprot NO.:O15263
Uniprot Entry Name:DFB4A_HUMAN
Gene Names:DEFB4A,DEFB102,DEFB2,DEFB4;,DEFB4B
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:24-64aa
Sequence:GIGDPVTCLK SGAICHPVFC PRRYKQIGTC GLPGTKCCKK P
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:4.3 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using immature human dendritic cells is in a concentration range of 10-100 ng/ml.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Beta-defensin 2, hBD-2, Defensin, beta 2, Skin-antimicrobial peptide 1, SAP1
Relevance:Has antibacterial activity. {ECO:0000305}.
PubMed ID:9202117; 9831658; 10603376; 10837369; 15489334; 12010514; 10906336; 11714914
Function:Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Can bind to both human and mouse CCR6 and induce chemotactic activity of CCR6-expressing cells
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Beta-defensin family, LAP/TAP subfamily
Tissue Specificity:Expressed in the skin and respiratory tract.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:2767
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=105924
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:100289462
STRING Database Link:https://string-db.org/network/9606.ENSP00000424598
OMIM Database Link:https://www.omim.org/entry/602215602215602215