Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Microbiology
Uniprot NO.:Q8WTQ1
Uniprot Entry Name:D104A_HUMAN
Gene Names:DEFB104A,DEFB104,DEFB4;,DEFB104B
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:23-72aa
Sequence:EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:6.0 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Beta-defensin 4, DEFB-4, hBD-4, Defensin, beta 104,
Relevance:Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. {ECO:0000269|PubMed:11481241}.
PubMed ID:11481241; 15489334
Function:Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Beta-defensin family
Tissue Specificity:High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:18115
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=559507
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:107984148
STRING Database Link:https://string-db.org/network/9606.ENSP00000322191
OMIM Database Link: