Recombinant Human Beta-defensin 104 protein(DEFB104A) (Active)

Recombinant Human Beta-defensin 104 protein(DEFB104A) (Active)

CSB-AP003061HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Microbiology

Uniprot NO.:Q8WTQ1

Uniprot Entry Name:D104A_HUMAN

Gene Names:DEFB104A,DEFB104,DEFB4;,DEFB104B

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:23-72aa

Sequence:EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:6.0 kDa

Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration range of 0.1-100.0 ng/ml.

Purity:>98% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 130 mM NaCl

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:Beta-defensin 4, DEFB-4, hBD-4, Defensin, beta 104,

Relevance:Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103. {ECO:0000269|PubMed:11481241}.

PubMed ID:11481241; 15489334

Function:Has antimicrobial activity. Synergistic effects with lysozyme and DEFB103.

Involvement in disease:

Subcellular Location:Secreted

Protein Families:Beta-defensin family

Tissue Specificity:High expression in the testis. Gastric antrum exhibited relatively high levels. A lower expression is observed in uterus and neutrophils thyroid gland, lung, and kidney. No detectable expression in other tissues tested.

Paythway:

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:18115

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=559507

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:107984148

STRING Database Link:https://string-db.org/network/9606.ENSP00000322191

OMIM Database Link:

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