Phospho-Histone H2AX (S139) Antibody - Cat. #: CSB-RA010097A139phHU

CSB-RA010097A139phHU

Size :50ul

Clone Number:1F10

Aliases:Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX

Product Type:Recombinant Antibody

Immunogen Species:Human

UniProt ID:P16104

Immunogen:A synthesized peptide

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:3000-1:10000

Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:H2AFX

Research Areas:Epigenetics and Nuclear Signaling