Size :50ul
Clone Number:1F10
Aliases:Histone H2AX, H2a/x, Histone H2A.X, H2AFX, H2AX
Product Type:Recombinant Antibody
Immunogen Species:Human
UniProt ID:P16104
Immunogen:A synthesized peptide
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, WB; Recommended dilution: WB:1:3000-1:10000
Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:H2AFX
Research Areas:Epigenetics and Nuclear Signaling