Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia. Protects cells against apoptosis in response to hypoxia and oxidative stress.
Immunogen:pyruvate dehydrogenase kinase, isozyme 1
Synonyms:PDH kinase 1, PDHK1, PDK1, Pyruvate dehydrogenase kinase isoform 1
Observed MW:50kd
Uniprot ID:Q15118
Reactivity:Human, Mouse, Rat
Tested Application:ELISA, IHC, WB, IP
Recommended dilution:WB: 1:500-1:2000; IP: 1:500-1:2000; IHC: 1:50-1:500
Gene ID:5163
Research Area:Signal Transduction, Metabolism