Size :50ug
Clone Number:
Aliases:DLX5Homeobox protein DLX-5 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P56178
Immunogen:Recombinant Human Homeobox protein DLX-5 protein (1-249AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200
Background:Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5\'-TAATTA-3\' consensus sequence for DNA-binding.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:DLX5
Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Signal transduction; Stem cells