Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:P15514
Uniprot Entry Name:AREG_HUMAN
Gene Names:AREG,SDGF;,AREGB
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:101-198aa
Sequence:SVRVEQVVKP PQNKTESENT SDKPKRKKKG GKNGKNRRNR KKKNPCNAEF QNFCIHGECK YIEHLEAVTC KCQQEYFGER CGEKSMKTHS MIDSSLSK
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:11.3 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine Balb/c 3T3 cells is between 5-10 ng/ml.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:AR, CRDGF
Relevance:Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
PubMed ID:2325643; 15489334; 2466334; 3413110; 2017164; 1333777; 22967896; 7679104; 17607000;
Function:Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.
Involvement in disease:
Subcellular Location:Membrane, Single-pass membrane protein
Protein Families:Amphiregulin family
Tissue Specificity:
Paythway:ErbBsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:651
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=270833
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:374
STRING Database Link:https://string-db.org/network/9606.ENSP00000370227
OMIM Database Link:https://www.omim.org/entry/104640104640104640