Size:100ug
Purification:Immunogen affinity purified
Form:liquid
Purity:?95% as determined by SDS-PAGE
Host:Rabbit
Clonality:polyclonal
Clone ID:
Isotype:IgG
Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)
Background:Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex(PubMed:11590237, PubMed:15485811, PubMed:15824131). Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum(ER); the function is proposed to depend on its association in the interphase NRZ complex which is believed to play a role in SNARE assembly at the ER(PubMed:15029241).
Immunogen:ZW10, kinetochore associated, homolog(Drosophila)
Synonyms:HZW10, KNTC1AP, ZW10
Observed MW:90 kDa
Uniprot ID:O43264
Reactivity:Human
Tested Application:ELISA, WB
Recommended dilution:WB: 1:500-1:5000; IP: 1:200-1:2000
Gene ID:9183
Research Area:Cell Division and Proliferation, Developmental biology