Size :50ug
Clone Number:
Aliases:DTEF 1 antibody; DTEF-1 antibody; DTEF1 antibody; ETFR 1 antibody; ETFR1 antibody; TEA domain family member 3 antibody; TEA domain family member 5 antibody; TEAD 3 antibody; TEAD-3 antibody; Tead3 antibody; TEAD3_HUMAN antibody; TEAD5 antibody; TEF 5 antibody; TEF5 antibody; Transcriptional enhancer factor 5 antibody; Transcriptional enhancer factor TEF 5 (DTEF 1) antibody; Transcriptional enhancer factor TEF 5 antibody; Transcriptional enhancer factor TEF-5 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:Q99594
Immunogen:Recombinant Human Transcriptional enhancer factor TEF-5 protein (112-435AA)
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:
Background:Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.
Clonality:Polyclonal
Isotype:IgG
Purification Method:>95%, Protein G purified
Conjugate:FITC
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:TEAD3
Research Areas:Epigenetics and Nuclear Signaling; Developmental biology