Size :100ul
Clone Number:
Aliases:hMAD 2; hMAD-2; hSMAD2; JV18 1; JV18; JV18; JV18-1; JV181; MAD; MAD; MAD homolog 2; MAD Related Protein 2; Mad-related protein 2; MADH2; MADR2; MGC22139; MGC34440; Mothers Against Decapentaplegic Homolog 2; Mothers Against Decapentaplegic Homolog 2;
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:Q15796
Immunogen:Purified recombinant human SMAD2 protein fragments expressed in E.coli.
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,WB,ICC;Recommended dilution:WB:1:500-1:5000,ICC:1:50-1:200
Background:Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases.Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and,on formation of the SMAD2/SMAD4 complex,activates transcription.May act as a tumor suppressor in colorectal carcinoma.Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:Affinity purified
Conjugate:Non-conjugated
Buffer:Ascites
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:SMAD2
Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism;Signal transduction?Stem cells