Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:O55145
Uniprot Entry Name:X3CL1_RAT
Gene Names:Cx3cl1,Acc1,Fkn,Scyd1
Species:Rattus norvegicus (Rat)
Source:E.Coli
Expression Region:25-100aa
Sequence:QHLGMTKCNI TCHKMTSPIP VTLLIHYQLN QESCGKRAII LETRQHRHFC ADPKEKWVQD AMKHLDHQTA ALTRNG
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:8.8 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human monocytes is in a concentration of 5.0-10 ng/ml.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, ,
Relevance:The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1.
PubMed ID:9724801
Function:Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1 and to integrins ITGAV
Involvement in disease:
Subcellular Location:Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted
Protein Families:Intercrine delta family
Tissue Specificity:Highest levels in brain (neurons). Significant levels in kidney, heart, lung and adrenal gland.
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=107266
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?rno:89808
STRING Database Link:https://string-db.org/network/10116.ENSRNOP00000022128
OMIM Database Link: