Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q10746
Uniprot Entry Name:CXCL3_RAT
Gene Names:Cxcl3,Cinc2
Species:Rattus norvegicus (Rat)
Source:E.Coli
Expression Region:33-101aa
Sequence:RELRCQCLKT LPRVDFENIQ SLTVTPPGPH CTQTEVIATL KDGQEVCLNP QAPRLQKIIQ KLLKSDKSS
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:7.8 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human CXCR2 transfected murine BaF3 cells is in a concentration range of 5-50 ng/ml.
Purity:>96% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered 20 mM PB, pH 7.4, 50 mM NaCl
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Cytokine-induced neutrophil chemoattractant 2, Macrophage inflammatory protein 2-alpha/beta, MIP2-alpha/beta
Relevance:Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. {ECO:0000250, ECO:0000269|PubMed:8043001, ECO:0000269|PubMed:8607872}.
PubMed ID:8043001; 9576061; 8471066; 8607872
Function:Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Intercrine alpha (chemokine CxC) family
Tissue Specificity:
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=10525
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?rno:171551
STRING Database Link:https://string-db.org/network/10116.ENSRNOP00000038520
OMIM Database Link: