Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P47993
Uniprot Entry Name:XCL1_MOUSE
Gene Names:Xcl1,Lptn,Ltn,Scyc1
Species:Mus musculus (Mouse)
Source:E.Coli
Expression Region:22-114aa
Sequence:VGTEVLEESS CVNLQTQRLP VQKIKTYIIW EGAMRAVIFV TKRGLKICAD PEAKWVKAAI KTVDGRASTR KNMAETVPTG AQRSTSTAIT LTG
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:10.1 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a chemotaxis bioassay using human XCR1 transfected murine BaF3 cells is less than 100 ng/ml, corresponding to a specific activity of ? 1.0 ×104 IU/mg.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:C motif chemokine 1, Lymphotaxin, Small-inducible cytokine C1
Relevance:Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
PubMed ID:7973732; 7875320; 9199871; 15489334
Function:Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Intercrine gamma family
Tissue Specificity:Expressed in activated CD8(+) T cells. In the thymus, expressed by medullary thymic epithelial cells.
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=190
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:16963
STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000027860
OMIM Database Link: