Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P25085
Uniprot Entry Name:IL1RA_MOUSE
Gene Names:Il1rn,Il-1ra
Species:Mus musculus (Mouse)
Source:E.Coli
Expression Region:27-178aa
Sequence:RPSGKRPCKM QAFRIWDTNQ KTFYLRNNQL IAGYLQGPNI KLEEKIDMVP IDLHSVFLGI HGGKLCLSCA KSGDDIKLQL EEVNITDLSK NKEEDKRFTF IRSEKGPTTS FESAACPGWF LCTTLEADRP VSLTNTPEEP LIVTKFYFQE DQ
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:17.3 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inhibiting IL-1?- dependent proliferation of murine D10S cells is less than 50 ng/ml, corresponding to a specific activity of ? 2.0 × 104 IU/mg in the presence of 50 pg/ml rHuIL-1?.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-1RN, IRAP, IL1 inhibitor
Relevance:Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
PubMed ID:1828262; 1830498; 8003626; 9550387; 1828896; 1834470
Function:Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity.
Involvement in disease:
Subcellular Location:Isoform 1: Secreted, SUBCELLULAR LOCATION: Isoform 2: Cytoplasm
Protein Families:IL-1 family
Tissue Specificity:
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=882
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:16181
STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000110126
OMIM Database Link: