Size:20ug. Other sizes are also available. For further information, please contact us.
Research Areas:Others
Uniprot ID:Q504P2
Gene Names:Clec12a
Organism:Mus musculus (Mouse)
AA Sequence:YTTLATEMIKSNQLQRAKEELQENVFLQLKHNLNSSKKIKNLSAMLQSTATQLCRELYSKEPEHKCKPCPKGSEWYKDSCYSQLNQYGTWQESVMACSARNASLLKVKNKDVLEFIKYKKLRYFWLALLPRKDRTQYPLSEKMFLSEESERSTDDIDKKYCGYIDRVNVYYTYCTDENNIICEETASKVQLESVLNGLPEDSR
Expression Region:65-267aa
Sequence Info:Extracellular Domain
Source:Baculovirus
Tag Info:N-terminal 10xHis-tagged and C-terminal Myc-tagged
MW:27.8 kDa
Alternative Name(s):C-type lectin-like molecule 1 (CLL-1) (Myeloid inhibitory C-type lectin-like receptor) (MICL)
Relevance:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Reference:"KLRL1, a novel killer cell lectinlike receptor, inhibits natural killer cell cytotoxicity." Han Y., Zhang M., Li N., Chen T., Zhang Y., Wan T., Cao X. Blood 104:2858-2866(2004)
Purity:Greater than 85% as determined by SDS-PAGE.
Form:Liquid or Lyophilized powder
Buffer:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function:Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Involvement in disease:
Subcellular Location:Cell membrane, Single-pass type II membrane protein
Protein Families:
Tissue Specificity:
Paythway:
HGNC Database Link:
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Mm&CID=90241
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?mmu:232413
STRING Database Link:https://string-db.org/network/10090.ENSMUSP00000063627
OMIM Database Link:
Lead Time Guidance:3-7 business days