Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:Q9NP84
Uniprot Entry Name:TNR12_HUMAN
Gene Names:TNFRSF12A,FN14
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:28-80aa
Sequence:EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:5.6 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by inhibiting TWEAK- dependent proliferation of human umbilical vein endothelial cells (HUVEC) is less than 30 ng/ml, corresponding to a specific activity of ? 3.3 × 104 IU/mg, in the presence of 15 ng/ml of rHuTWEAK.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:Fibroblast growth factor-inducible immediate-early response protein 14, Tweak-receptor, TweakR, CD antigen CD266,
Relevance:Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.
PubMed ID:10751351; 15489334; 11728344; 19241374
Function:Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
Involvement in disease:
Subcellular Location:Membrane, Single-pass type I membrane protein
Protein Families:
Tissue Specificity:Highly expressed in heart, placenta and kidney. Intermediate expression in lung, skeletal muscle and pancreas.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:18152
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=355899
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:51330
STRING Database Link:https://string-db.org/network/9606.ENSP00000326737
OMIM Database Link:https://www.omim.org/entry/605914605914605914