Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:P41273
Uniprot Entry Name:TNFL9_HUMAN
Gene Names:TNFSF9
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:71-254aa
Sequence:REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:19.4 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by stimulation of IL8 production using human PBMC is less than 10 ng/ml, corresponding to a specific activity of ? 1.0 × 105 IU/mg.
Purity:>95% as determined by SDSPAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:4-1BB ligand,
Relevance:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}.
PubMed ID:8088337; 15489334; 20032458
Function:Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Involvement in disease:
Subcellular Location:Membrane, Single-pass type II membrane protein
Protein Families:Tumor necrosis factor family
Tissue Specificity:Expressed in brain, placenta, lung, skeletal muscle and kidney.
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:11939
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=1524
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:8744
STRING Database Link:https://string-db.org/network/9606.ENSP00000245817
OMIM Database Link:https://www.omim.org/entry/606182606182606182