Recombinant Human Platelet factor 4 protein(PF4) (Active)

Recombinant Human Platelet factor 4 protein(PF4) (Active)

CSB-AP000661HU
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Size:100ug. Other sizes are also available. Please contact us.

Research Areas:Immunology

Uniprot NO.:P02776

Uniprot Entry Name:PLF4_HUMAN

Gene Names:PF4,CXCL4,SCYB4

Species:Homo sapiens (Human)

Source:E.Coli

Expression Region:32-101aa

Sequence:EAEEDGDLQC LCVKTTSQVR PRHITSLEVI KAGPHCPTAQ LIATLKNGRK ICLDLQAPLY KKIIKKLLES

Protein Description:Full Length of Mature Protein

Tag Info:Tag-Free

Mol. Weight:7.8 kDa

Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human fibroblasts is in a concentration of 1.0-10 ng/ml.

Purity:>97% as determined by SDS-PAGE and HPLC.

Endotoxin:Less than 1.0 EU/µg as determined by LAL method.

Form:Lyophilized powder

Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4

Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.

Alternative Name/ Alias:PF-4, Iroplact, Oncostatin-A, ,

Relevance:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. {ECO:0000269|PubMed:7644496}.

PubMed ID:3098319; 1695112; 11468158; 15815621; 15489334; 893407; 267922; 601757; 6445090; 7644496; 23536183; 8031770; 7547867

Function:Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Involvement in disease:

Subcellular Location:Secreted

Protein Families:Intercrine alpha (chemokine CxC) family

Tissue Specificity:

Paythway:Chemokinesignalingpathway

HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:8861

UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=81564

KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:5196

STRING Database Link:https://string-db.org/network/9606.ENSP00000296029

OMIM Database Link:https://www.omim.org/entry/173460173460173460

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