Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P47992
Uniprot Entry Name:XCL1_HUMAN
Gene Names:XCL1,LTN,SCYC1
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:23-114aa
Sequence:GSEVSDKRTC VSLTTQRLPV SRIKTYTITE GSLRAVIFIT KRGLKVCADP QATWVRDVVR SMDRKSNTRN NMIQTKPTGT QQSTNTAVTL TG
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:10.2 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 10-100 ng/ml.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:ATAC, Cytokine SCM-1, Lymphotaxin, SCM-1-alpha, Small-inducible cytokine C1
Relevance:Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
PubMed ID:7602097; 7875320; 7615002; 8849694; 16710414; 15489334; 11601972
Function:Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Intercrine gamma family
Tissue Specificity:Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Paythway:Chemokinesignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:10645
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=458346
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:6375
STRING Database Link:https://string-db.org/network/9606.ENSP00000356792
OMIM Database Link:https://www.omim.org/entry/600250600250600250