Size:100ug. Other sizes are also available. For further information, please contact us.
Research Areas:Signal Transduction
Uniprot ID:P10997
Gene Names:IAPP
Organism:Homo sapiens (Human)
AA Sequence:KCNTATCATQRLANFLVHSSNNFGAILSSTNVGSNTY
Expression Region:34-70aa
Sequence Info:Partial
Source:Yeast
Tag Info:N-terminal 6xHis-tagged
MW:5.9 kDa
Alternative Name(s):PYY-I
Relevance:This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility.
Reference:The PP-fold solution structure of human polypeptide YY and human PYY3-36 as determined by NMR.Nygaard R., Nielbo S., Schwartz T.W., Poulsen F.M.Biochemistry 45:8350-8357(2006)
Purity:Greater than 90% as determined by SDS-PAGE.
Form:Liquid or Lyophilized powder
Buffer:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function:Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Calcitonin family
Tissue Specificity:
Paythway:
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5329
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=46835
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3375
STRING Database Link:https://string-db.org/network/9606.ENSP00000240652
OMIM Database Link:https://www.omim.org/entry/147940147940147940
Lead Time Guidance:3-7 business days