Size:100ug. Other sizes are also available. For further information, please contact us.
Research Areas:Immunology
Uniprot ID:P05113
Gene Names:IL5
Organism:Homo sapiens (Human)
AA Sequence:IPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
Expression Region:20-134aa
Sequence Info:Full Length of Mature Protein
Source:Yeast
Tag Info:C-terminal 6xHis-tagged
MW:15.1 kDa
Alternative Name(s):B-cell differentiation factor I Eosinophil differentiation factor T-cell replacing factor Short name: TRF
Relevance:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Reference:"Human interleukin-5 expressed in Escherichia coli: assignment of the disulfide bridges of the purified unglycosylated protein." Proudfoot A.E.I., Davies J.G., Turcatti G., Wingfield P.T. FEBS Lett. 283:61-64(1991)
Purity:Greater than 85% as determined by SDS-PAGE.
Form:Liquid or Lyophilized powder
Buffer:If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Storage:The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20?/-80?. The shelf life of lyophilized form is 12 months at -20?/-80?.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Function:Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-5 family
Tissue Specificity:
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:6016
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=2247
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3567
STRING Database Link:https://string-db.org/network/9606.ENSP00000231454
OMIM Database Link:https://www.omim.org/entry/147850147850147850
Lead Time Guidance:25-35 business days