Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:Q9UHD0
Uniprot Entry Name:IL19_HUMAN
Gene Names:IL19,ZMDA1
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:25-177aa
Sequence:LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM SSA
Protein Description:Partial of AF192498
Tag Info:Tag-Free
Mol. Weight:17.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using human IL-20R? and human IL-20R? co-transfected murine BaF3 pro-B cells is less than 1.5 ng/ml, corresponding to a specific activity of ? 6.7×105 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IL-19, NG.1
Relevance:May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity). {ECO:0000250}.
PubMed ID:11196675; 12370360; 19906316; 16710414; 15340161; 12403790
Function:May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis (By similarity).
Involvement in disease:
Subcellular Location:Secreted
Protein Families:IL-10 family
Tissue Specificity:
Paythway:Jak-STATsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5990
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=661017
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:29949
STRING Database Link:https://string-db.org/network/9606.ENSP00000343000
OMIM Database Link:https://www.omim.org/entry/605687605687605687