Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P01579
Uniprot Entry Name:IFNG_HUMAN
Gene Names:IFNG
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:M+24-166aa
Sequence:MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQ
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:16.9 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as measured in anti-viral assays using human HeLa cells infected with encephalomyocarditis (EMC) virus is 0.15-0.80 ng/ml.
Purity:>98% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:IFN-gamma,
Relevance:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
PubMed ID:6180322; 6173769; 2860101; 6329718; 6176945; 19054851; 15489334; 6427223; 3109913; 2504704; 1902591; 7617032; 10860730; 10986460; 1525157; 15327519
Function:Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
Involvement in disease:Aplastic anemia (AA)
Subcellular Location:Secreted
Protein Families:Type II (or gamma) interferon family
Tissue Specificity:Released primarily from activated T lymphocytes.
Paythway:HIF-1signalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:5438
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=856
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:3458
STRING Database Link:https://string-db.org/network/9606.ENSP00000229135
OMIM Database Link:https://www.omim.org/entry/147570147570147570