Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Immunology
Uniprot NO.:P78423
Uniprot Entry Name:X3CL1_HUMAN
Gene Names:CX3CL1,FKN,NTT,SCYD1,A-152E5.2
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:25-100aa
Sequence:QHHGVTKCNI TCSKMTSKIP VALLIHYQQN QASCGKRAII LETRQHRLFC ADPKEQWVKD AMQHLDRQAA ALTRNG
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:8.6 kDa
Biological_Activity:Fully biologically active when compared to standard. The biological activity determined by a chemotaxis bioassay using human T-lymphocytes is in a concentration of 5.0-10 ng/ml.
Purity:>97% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:C-X3-C motif chemokine 1, Neurotactin, Small-inducible cytokine D1, ,
Relevance:The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium. Binds to CX3CR1. {ECO:0000269|PubMed:21829356}.
PubMed ID:9024663; 10493829; 15489334; 19838169; 22171320; 9931005; 10770945; 21829356
Function:Acts as a ligand for both CX3CR1 and integrins. Binds to CX3CR1
Involvement in disease:
Subcellular Location:Cell membrane, Single-pass type I membrane protein, SUBCELLULAR LOCATION: Processed fractalkine: Secreted
Protein Families:Intercrine delta family
Tissue Specificity:Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Small intestine, colon, testis, prostate, heart, brain, lung, skeletal muscle, kidney and pancreas. Most abundant in the brain and heart.
Paythway:Chemokinesignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:10647
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=531668
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:6376
STRING Database Link:https://string-db.org/network/9606.ENSP00000006053
OMIM Database Link:https://www.omim.org/entry/601880601880601880