Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:P08620
Uniprot Entry Name:FGF4_HUMAN
Gene Names:FGF4,HST,HSTF1,KS3
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:25-206aa
Sequence:GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL
Protein Description:Partial
Tag Info:Tag-Free
Mol. Weight:19.8 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by thymidine uptake assay using FGFreceptors transfected BaF3 cells is less than 0.5 ng/ml, corresponding to a specific activity of ? 2.0 × 106 IU/mg.
Purity:>96% as determined by SDSPAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4, 300 mM NaCl
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:FGF-4, HST, HST-1, HSTF-1, Heparin-binding growth factor 4
Relevance:Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. {ECO:0000269|PubMed:8663044}.
PubMed ID:18192227; 2959959; 2953031; 2957062; 8663044; 20094046; 11486033
Function:Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
Involvement in disease:
Subcellular Location:Secreted
Protein Families:Heparin-binding growth factors family
Tissue Specificity:
Paythway:MAPKsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:3682
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=1755
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:2249
STRING Database Link:https://string-db.org/network/9606.ENSP00000168712
OMIM Database Link:https://www.omim.org/entry/164980164980164980