Size:100ug. Other sizes are also available. Please contact us.
Research Areas:Cancer
Uniprot NO.:O60258
Uniprot Entry Name:FGF17_HUMAN
Gene Names:FGF17,UNQ161/PRO187
Species:Homo sapiens (Human)
Source:E.Coli
Expression Region:23-216aa
Sequence:M+TQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT
Protein Description:Full Length of Mature Protein
Tag Info:Tag-Free
Mol. Weight:22.6 kDa
Biological_Activity:Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine balb/c 3T3 cells is less than 10 ng/ml, corresponding to a specific activity of ?1.0 × 105 IU/mg.
Purity:>95% as determined by SDS-PAGE and HPLC.
Endotoxin:Less than 1.0 EU/µg as determined by LAL method.
Form:Lyophilized powder
Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4
Reconstitution:We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week.
Alternative Name/ Alias:FGF-17,
Relevance:Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. {ECO:0000269|PubMed:16597617}.
PubMed ID:9514906; 12975309; 15489334; 16597617; 20094046; 23643382
Function:Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
Involvement in disease:Hypogonadotropic hypogonadism 20 with or without anosmia (HH20)
Subcellular Location:Secreted
Protein Families:Heparin-binding growth factors family
Tissue Specificity:Preferentially expressed in the embryonic brain.
Paythway:MAPKsignalingpathway
HGNC Database Link:https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:3673
UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Hs&CID=248192
KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?hsa:8822
STRING Database Link:https://string-db.org/network/9606.ENSP00000352414
OMIM Database Link:https://www.omim.org/entry/603725603725603725