Size :50ul
Clone Number:4D2G7
Aliases:Podocalyxin, GCTM-2 antigen, Gp200, Podocalyxin-like protein 1, PC, PCLP-1, PODXL, PCLP, PCLP1
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:O00592
Immunogen:Recombinant Human PODXL protein
Raised in:Mouse
Species Reactivity:Human, Mouse, Rat
Tested Applications:ELISA, WB, IHC, IP, IF, FC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200, IP:1:200-1:2000
Background:Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
Clonality:Monoclonal
Isotype:IgG2b
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:PODXL
Research Areas:Cancer; Cardiovascular; Signal transduction; Stem cells