Size :50ul
Clone Number:8D4
Aliases:Nuclear pore complex protein Nup153 (153 kDa nucleoporin) (Nucleoporin Nup153), NUP153
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P49790
Immunogen:A synthesized peptide derived from human Nup153
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:50-1:200, IF:1:20-1:200
Background:Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with TPR, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Mediates TPR anchoring to the nuclear membrane at NPC. The repeat-containing domain may be involved in anchoring other components of the NPC to the pore membrane. Possible DNA-binding subunit of the nuclear pore complex (NPC).
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:NUP153
Research Areas:Epigenetics and Nuclear Signaling; Tags & Cell Markers; Signal transduction