MEN1 Antibody - Cat. #: CSB-RA242999A0HU

SKU: CSB-RA242999A0HU

Size :50ul

Clone Number:8G11

Aliases:Menin, MEN1, SCG2

Product Type:Recombinant Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O00255

Immunogen:A synthesized peptide derived from human Menin

Raised in:

Species Reactivity:Human

Tested Applications:ELISA, WB; Recommended dilution: WB:1:500-1:5000

Background:Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

Clonality:Monoclonal

Isotype:Rabbit IgG

Purification Method:Affinity-chromatography

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEN1

Research Areas:Epigenetics and Nuclear Signaling; Cancer