Size :100ul
Clone Number:
Aliases:
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P20701
Immunogen:Recombinant Protein
Raised in:Mouse
Species Reactivity:Human
Tested Applications:ELISA,IF,FC;Recommended dilution:IF:1:100-1:200
Background:4A122 reacts with CD11a, a 180 kDa molecule. CD11a is the a chain of the leukocyte function associated antigen-1 (LFA-1a), and is expressed on all leukocytes including T and B cells, monocytes, and granulocytes, but is absent on non-hematopoietic tissue and human platelets. CD11/CD18 (LFA-1), a member of the integrin subfamily, is a leukocyte adhesion receptor that is essential for cell-to-cell contact, such as lymphocyte adhesion, NK and T-cell cytolysis, and T-cell proliferation. CD11/CD18 is also involved in the interaction of leucocytes with endothelium.*CD11a antibody has been used to reduces graft failure for bone marrow grafts in immunodeficient children. This clone is cross reactive with non-human primate.1. Schlossman. S et al. (1995) Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York.2. Lub M et al. (1995) Immunol. Today 16:479.3. Sanchez-Mateos P et al. (1996) Cancer Biol. 7:99.
Clonality:Monoclonal
Isotype:IgG1
Purification Method:Affinity purified
Conjugate:Non-conjugated
Buffer:Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
Form:liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:ITGAL
Research Areas:Immunology;Signal transduction?Stem cells