Size :50ul
Clone Number:4G3
Aliases:Fructose-1,6-bisphosphatase 1 (FBPase 1) (EC 3.1.3.11) (D-fructose-1,6-bisphosphate 1-phosphohydrolase 1) (Liver FBPase), FBP1, FBP
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P09467
Immunogen:A synthesized peptide derived from human FBP1
Raised in:
Species Reactivity:Human
Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:50-1:200
Background:Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:FBP1
Research Areas:Epigenetics and Nuclear Signaling; Cancer; Metabolism; Signal transduction