Size :50ug
Clone Number:5A11E5
Aliases:Amyloid Beta (A4) Precursor Protein, ABPP, APP, Beta-Amyloid Peptide
Product Type:Monoclonal Antibody
Immunogen Species:Human
UniProt ID:P05067
Immunogen:Recombinant Human APP Protein
Raised in:Mouse
Species Reactivity:Human, Mouse
Tested Applications:ELISA, WB, IHC, IF; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:500, IF:1:50-1:200
Background:This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.
Clonality:Monoclonal
Isotype:
Purification Method:>95%, Protein G purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:APP
Research Areas:Neuroscience