Size :50ul
Clone Number:5F2
Aliases:Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5), APC, DP2.5
Product Type:Recombinant Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P25054
Immunogen:A synthesized peptide derived from human APC
Raised in:
Species Reactivity:Human, Rat
Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
Background:Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.
Clonality:Monoclonal
Isotype:Rabbit IgG
Purification Method:Affinity-chromatography
Conjugate:Non-conjugated
Buffer:Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:APC
Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cardiovascular; Cell biology; Stem cells