Size :50ul
Clone Number:
Aliases:H2A histone family member Z antibody; H2A.z antibody; H2A/z antibody; H2afz antibody; H2AZ antibody; H2AZ_HUMAN antibody; Histone H2A.Z antibody; MGC117173 antibody
Product Type:Polyclonal Antibody
Immunogen Species:Homo sapiens (Human)
UniProt ID:P0C0S5
Immunogen:Peptide sequence around site of Acetyl-Lys (7) derived from Human Histone H2A.Z
Raised in:Rabbit
Species Reactivity:Human
Tested Applications:ELISA, WB, ICC, IF, IP, ChIP; Recommended dilution: WB:1:200-1:2000, ICC:1:20-1:200, IF:1:20-1:200, IP:1:200-1:2000
Background:Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division.
Clonality:Polyclonal
Isotype:IgG
Purification Method:Antigen Affinity Purified
Conjugate:Non-conjugated
Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form:Liquid
Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names:H2AFZ
Research Areas:Epigenetics and Nuclear Signaling